2018-2020
The Immune Setpoint study is an observational study of 600 healthy volunteers, stratified by age and gender including a subset of individuals who will receive the yellow fever vaccination (YFV).
The project has the following partners supported by SVRI:
- Centre Hospitalier Universitaire Vaudois (CHUV)
- Instituto di ricerca in Biomedicina (IRB)
- University of Zurich
- Hôpital Universitaire Genevois (HUG)
The study objectives are :
- To investigate a large number of phenotypic and functional parameters (about 200) of innate and adaptive immunity
- To identify the Immune Setpoint in healthy individuals through:
- Validated and highly specific immunological markers defining phenotypic and functional distinct cell populations with assays of high-level reproducibility suitable for clinical monitoring
- Immunological markers shared by different cell types
- Exploratory markers
- To evaluate the impact of vaccination (notably YF and influenza vaccination) on the immune system
- To determine the relationship between the microbiome and the Immune Setpoint